Shaping BMP Morphogen Gradients through Enzyme-Substrate Interactions
نویسندگان
چکیده
منابع مشابه
Shaping BMP morphogen gradients through enzyme-substrate interactions.
Bone morphogenetic proteins (BMPs) regulate dorsal/ventral (D/V) patterning across the animal kingdom; however, the biochemical properties of certain pathway components can vary according to species-specific developmental requirements. For example, Tolloid (Tld)-like metalloproteases cleave vertebrate BMP-binding proteins called Chordins constitutively, while the Drosophila Chordin ortholog, Sh...
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Shh activity and at different distances from the source. The proper functioning of tissues and organs requires These observations provide unequivocal evidence that that each cell differentiate appropriately for its position. Shh acts directly on distant cells and therefore that Shh In many cases, the positional information that instructs forms a morphogen gradient in the developing neural cells...
متن کاملShaping BMP morphogen gradients in the Drosophila embryo and pupal wings
In the early Drosophila embryo, BMP-type ligands act as morphogens to suppress neural induction and to specify the formation of dorsal ectoderm and amnioserosa. Likewise, during pupal wing development, BMPs help to specify vein versus intervein cell fate. Here, we review recent data suggesting that these two processes use a related set of extracellular factors, positive feedback, and BMP hetero...
متن کاملShaping BMP morphogen gradients in the Drosophila embryo and pupal wing.
In the early Drosophila embryo, BMP-type ligands act as morphogens to suppress neural induction and to specify the formation of dorsal ectoderm and amnioserosa. Likewise, during pupal wing development, BMPs help to specify vein versus intervein cell fate. Here, we review recent data suggesting that these two processes use a related set of extracellular factors, positive feedback, and BMP hetero...
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Individuals of the same or closely related species can vary substantially in size. Still, the proportions within and between tissues are precisely kept. This adaptation of pattern with size termed scaling, is receiving a growing attention. We review experimental evidence for scaling, and describe theoretical models for mechanisms that scale morphogen gradients. We particularly note the Expansio...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2011
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2011.06.025