sGC stimulators in experimental pulmonary hypertension
نویسندگان
چکیده
منابع مشابه
New clinical results with sGC stimulators
Background Stimulators of the nitric oxide (NO) receptor soluble guanylate cyclase (sGC) are a new class of substances which enhance the biosynthesis of cyclic guanosin monophosphate (cGMP) independently from the presence of nitric oxide (NO). In pulmonary smooth muscle cells, increased intracellular cGMP concentrations lead to vasodilatation, making sGC-stimulators potentially useful for the t...
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Methods Single-lung ventilation (right sided) was induced in 7-wk old minipigs (4-5 kg BW). In each animal 5 repetitive cycles of 10 min. left lobe blockade were followed by 30 min. bilateral ventilation. Hemodynamics (e.g. mean pulmonary artery pressure (mPAP), blood pressure (BP)) and arterial hemoglobin saturation (SaO2) were monitored continuously. We compared 5 different groups (n=6 each):...
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Background: Pulmonary hypertension (PH) was defined for the first time in 1951 as primary pulmonary hypertension (PPH). Some studies emphasized on the role of genetics in the development of pulmonary hypertension in family members of affected patients. So, in this study we evaluated the prevalence of pulmonary hypertension in first degree family of patients with documented PPH. Methods: In thi...
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Necrosis, fibrinoid changes, and cellular infiltrations of pulmonary arterioles have been observed, among other alterations, in extreme pulmonary arterial hypertension. Whether these lesions are the cause or the effect of the high pressure, whether they are the consequence of spasm, or whether they are produced by some other mechanism such as hypersensitivity, remains to be established. Certain...
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Cardiac disease is the main cause of death in both forms of thalassemia; thalassemia major (TM) and thalassemia intermedia (TI). Pulmonary hypertension (PH) is one of the cardiopulmonary morbidities with high mortality that, if not treated, may trigger right-sided heart failure and premature death. PH is defined as a mean pulmonary artery pressure of ≥25 mmHg at rest or ≥30 mmHg during exercise...
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ژورنال
عنوان ژورنال: BMC Pharmacology
سال: 2007
ISSN: 1471-2210
DOI: 10.1186/1471-2210-7-s1-s3