Sexual dimorphism in glutathione metabolism and glutathione-dependent responses
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چکیده
منابع مشابه
Positive and negative transcriptional regulators of glutathione-dependent formaldehyde metabolism.
A glutathione (GSH)-dependent pathway is used for formaldehyde metabolism by a wide variety of prokaryotes and eukaryotes. In this pathway, S-hydroxymethylglutathione, produced by the reaction of formaldehyde with the thiolate moiety of glutathione, is the substrate for a GSH-dependent formaldehyde dehydrogenase (GSH-FDH). While expression of GSH-FDH often increases in the presence of metabolic...
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Mutations in the tricarboxylic acid (TCA) cycle enzyme fumarate hydratase (FH) are associated with a highly malignant form of renal cancer. We combined analytical chemistry and metabolic computational modelling to investigate the metabolic implications of FH loss in immortalized and primary mouse kidney cells. Here, we show that the accumulation of fumarate caused by the inactivation of FH lead...
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a GSH instability, as well as a low activity of glucose 6-phosphate-dehydrogenase were demonstrated in those cells (2-5). A similar hereditary abnormality of the erythrocytes has been described in Jews originating from oriental and Mediterranean countries (6-10). It is associated with a susceptibility to hemolysis by various agents such as fava beans, sulpha drugs, para-amino salicylic acid and...
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ژورنال
عنوان ژورنال: Redox Biology
سال: 2020
ISSN: 2213-2317
DOI: 10.1016/j.redox.2019.101410