Sex-specific BDNF and APOE ε4 genotype interactions on white matter hyperintensity volume
نویسندگان
چکیده
منابع مشابه
APOE ε4 status is associated with white matter hyperintensities volume accumulation rate independent of AD diagnosis
To assess the relationship between carriage of APOE ε4 allele and evolution of white matter hyperintensities (WMHs) volume, we longitudinally studied 339 subjects from the Alzheimer's Disease Neuroimaging Initiative cohort with diagnoses ranging from normal controls to probable Alzheimer's disease (AD). A purpose-built longitudinal automatic method was used to segment WMH using constraints deri...
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BACKGROUND Subcortical lacunar infarcts and white matter hyperintensities (WMH) are common neuroradiological findings, but few studies associate between these insults and cognition in a community-dwelling population. METHODS The Dallas Heart Study is a population-based initiative whose assessments included demographic and clinical findings including brain MRI and the Montreal Cognitive Assess...
متن کاملWhite matter hyperintensity penumbra.
BACKGROUND AND PURPOSE White matter hyperintensities (WMHs) are associated with progressive age-related cognitive decline and cardiovascular risk factors, but their biological relevance as indicators of generalized white matter injury is unclear. Diffusion tensor imaging provides more sensitive indications of subtle white matter disruption and can therefore clarify whether WMHs represent foci o...
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Background and Purpose—White matter hyperintensities have been associated with increased risk of stroke, cognitive decline, and dementia. Chronic kidney disease is a risk factor for vascular disease and has been associated with inflammation and endothelial dysfunction, which have been implicated in the pathogenesis of white matter hyperintensities. Few studies have explored the relationship bet...
متن کاملA Semi-Automated Method for Measuring White Matter Hyperintensity Volume
YongSoo Shim, M.D.*, Bora Yoon, M.D.†, Yun Jeong Hong, M.D.‡, A-Hyun Cho, M.D.*, Dong-Won Yang, M.D.* Department of Neurology*, The Catholic University of Korea, Seoul; Department of Neurology†, Konyang University College of Medicine, Daejeon; ‡Hyoja Geriatric Hospital, Yongin, Korea Background: White matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) have been considered as a r...
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ژورنال
عنوان ژورنال: Innovation in Aging
سال: 2020
ISSN: 2399-5300
DOI: 10.1093/geroni/igaa057.3252