Sex differences in drug abuse
نویسندگان
چکیده
منابع مشابه
Sex differences in drug abuse.
Sex differences are present for all of the phases of drug abuse (initiation, escalation of use, addiction, and relapse following abstinence). While there are some differences among specific classes of abused drugs, the general pattern of sex differences is the same for all drugs of abuse. Females begin regularly self-administering licit and illicit drugs of abuse at lower doses than do males, u...
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The premise of individualized or personalized medicine is that the intervention is tailored to the individual. Individualized therapy will accommodate differences in body size, differences in metabolism and elimination, as well as differences in response. One appropriate starting point for individualized therapy is to focus on sex differences. Men and women differ in critical molecular, genetic...
متن کاملSex Differences in Drug Disposition
Physiological, hormonal, and genetic differences between males and females affect the prevalence, incidence, and severity of diseases and responses to therapy. Understanding these differences is important for designing safe and effective treatments. This paper summarizes sex differences that impact drug disposition and includes a general comparison of clinical pharmacology as it applies to men ...
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Evidence is accumulating that the etiology, epidemiology, consequences and mechanisms that underlie drug abuse are different in males and females. In this review, we present examples of sex differences in all phases of drug abuse, including acquisition, steady-state maintenance, escalation, dysregulation, withdrawal, relapse and treatment. Most reported findings are based on laboratory research...
متن کاملSex-based differences in drug activity.
Physiologic differences between men and women affect drug activity, including pharmacokinetics and pharmacodynamics. Pharmacokinetics in women is affected by lower body weight, slower gastrointestinal motility, less intestinal enzymatic activity, and slower glomerular filtration rate. Because of delayed gastric emptying, women may need to extend the interval between eating and taking medication...
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ژورنال
عنوان ژورنال: Frontiers in Neuroendocrinology
سال: 2008
ISSN: 0091-3022
DOI: 10.1016/j.yfrne.2007.07.003