منابع مشابه
Sex Determination: Switch and Suppress
The transcription factor Dmrt1 regulates male sexual development from flies and worms to humans. A newly discovered function is to suppress female differentiation in the testes. Thus, the gonadal fate decision is not final but has to be actively maintained throughout life.
متن کاملSwitch genes and sex determination in the nematode C. elegans.
The development of the nematode C. elegans is highly invariant, and has been described in great detail. Many developmental mutations have been isolated and analysed; some of these identify switch genes, i.e. genes that control the choice between two developmental alternatives. It appears that the genetic controls of development in this animal are discrete, hierarchical and relatively simple. Th...
متن کاملSry: the master switch in mammalian sex determination.
SRY, the mammalian Y-chromosomal testis-determining gene, induces male sex determination. Recent studies in mice reveal that the major role of SRY is to achieve sufficient expression of the related gene Sox9, in order to induce Sertoli cell differentiation, which in turn drives testis formation. Here, we discuss the cascade of events triggered by SRY and the mechanisms that reinforce the differ...
متن کاملSex determination and differentiation.
N Engl J Med 2004;350:367-78. Copyright © 2004 Massachusetts Medical Society. ex determination, which depends on the sex-chromosome complement of the embryo, is established by multiple molecular events that direct the development of germ cells, their migration to the urogenital ridge, and the formation of either a testis, in the presence of the Y chromosome (46,XY), or an ovary in the absence o...
متن کاملSex Determination, Sex Ratios and Genetic Conflict
Genetic mechanisms of sex determination are unexpectedly diverse and change rapidly during evolution. We review the role of genetic conflict as the driving force behind this diversity and turnover. Genetic conflict occurs when different components of a genetic system are subject to selection in opposite directions. Conflict may occur between genomes (including paternal-maternal and parentalzygo...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2011
ISSN: 0960-9822
DOI: 10.1016/j.cub.2011.07.026