Sevoflurane modulates both GABAA and GABAB receptors in area CA1 of rat hippocampus
نویسندگان
چکیده
منابع مشابه
Gabaa and Gabab Receptors
Since the introduction of the alpha function by Rall in 1967 12], there has been signii-cant progress in our understanding of the molecular events underlying synaptic transmission. Particular receptor types have been identiied and their activation kinetics characterized. It is now possible to develop models of these receptors, using a formalism similar to that introduced by Hodgkin and Huxley 9...
متن کاملGABAB Receptors Regulate Extrasynaptic GABAA Receptors.
Tonic inhibitory GABA(A) receptor-mediated currents are observed in numerous cell types in the CNS, including thalamocortical neurons of the ventrobasal thalamus, dentate gyrus granule cells, and cerebellar granule cells. Here we show that in rat brain slices, activation of postsynaptic GABA(B) receptors enhances the magnitude of the tonic GABA(A) current recorded in these cell types via a path...
متن کاملAspirin changes short term synaptic plasticity in CA1 area of the rat hippocampus
Introduction: The prostaglandin E2 (PGE2), a cyclooxygenase (COX) product, play critical roles in the synaptic plasticity. Therefore, long term use of COX inhibitors may impair the synaptic plasticity. Considering the wide clinical administration of aspirin and its unknown effects on information processing in the brain, the effect of aspirin and sodium salicylate on the short term synaptic p...
متن کاملThe Role of Estrogen Receptors on Spatial Learning and Memory in CA1 Region of Adult Male Rat Hippocampus
The hippocampal system plays an important role in memory function. Neurohormones like androgens and estrogens that syntheses in hippocampus have an important role in learning and memory. Many biological effects of estrogens in the brain via estrogenic receptors (ERs) are investigated. The current research has conducted to assess the effect of estrogenic receptors on spatial discrimination in ra...
متن کاملBoth GABAA and GABAB receptors mediate vagal inhibition in nucleus tractus solitarii neurones in anaesthetized rats.
GABA receptors in the nucleus tractus solitarius (NTS) are known to play an important role in the mediation/modulation of various cardiovascular/respiratory functions. Vagal afferent activation of these neurones usually evokes an initial excitation followed by a long lasting inhibition. The present study examines the role of GABA(B) as well as GABA(A) receptors in the mediation of this inhibiti...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1997
ISSN: 0007-0912
DOI: 10.1093/bja/78.1.60