Severe Pernicious Anemia With Normal Serum B12 and Normal Mean Corpuscular Volume

Thalassemia and Hemoglobinopathy Despite Normal Level of Hemoglobin Concentration and Normal Mean Corpuscular Volume

The small mean corpuscular volume (MCV) of red blood cell is one of the indicators for thalassemia and hemoglobinopathy screening. As other screening methods, it may have some degrees of limitation. The retrospective study was performed among 104 patients who had various kinds of thalassemia or hemoglobinopathy despite having normal hemoglobin (Hb) concentration and normal mean corpuscular volu...

Prevalence of pernicious anemia in patients with macrocytic anemia and low serum B12

OBJECTIVE The current research evaluated the prevalence of pernicious anemia (PA) in patients with macrocytic anemia (high MCV) and low serum B12 in Riyadh. METHODS Blood testing was done in 77 patients (males: 45.5%, females: 54.5%) with macrocytic anemia; 84 patients; (males: 23.8%, females: 76.2%) with low serum B12 and 30 healthy subjects. Complete blood count, differential count, folic a...

Reversal of severe osteoporosis with vitamin B12 and etidronate therapy in a patient with pernicious anemia.

Pernicious anemia has recently been recognized as a risk factor for osteoporosis and fractures. Although vitamin B12 is important for osteoblast function, the effect of vitamin B12 replacement in states of vitamin B12 deficiency on bone density and fracture incidence is not known. We report 2-year follow-up data from a patient with severe osteoporosis, multiple vertebral compression fractures, ...

B12 binding protein deficiency in pernicious anemia.

Huge Dose Vitamin B12 (Vit B12) Treatment for Pernicious Anemia

The recent letter by Aytaç and colleagues, entitled “Poland syndrome associated with pernicious anemia and gastric dysplasia”, gives me an opportunity to question the vitamin B12 dose administered for the treatment of pernicious anemia [1]. Vitamin B12 was initiated by the authors (1000 μg daily for 5 days, 1000 μg weekly for 4 weeks, and then 1000 μg monthly for life) without taking into accou...