Severe nosocomial pneumonia – emphasis on nebulized tobramycin
نویسندگان
چکیده
منابع مشابه
Inhaled Tobramycin in the Treatment of Nosocomial Pneumonia in Severe Sepsis
Copyright: © 2013 Kuzovlev AN. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Nosocomial Pneumonia (NP) is the most prevalent intensive care unit infection with the attributable mortality between 5.8 to 27% [...
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We report two cases of severe late-onset nosocomial pneumonia caused by Chlamydophila pneumaniae. The clinical course of the disease in these patients suggests that nosocomial pneumonia caused by this agent can lead to profound respiratory insufficiency and acute respiratory distress syndrome, particularly in patients with significant comorbidities and during the postoperative period. Intraveno...
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Delay in initiating appropriate antibiotic treatment in patients with severe nosocomial pneumonia (SNP) is associated with a more unfavorable prognosis,1-6 longer hospital stays, and consequently higher healthcare costs. Moreover, in the context of ventilator-associated pneumonia (VAP), changing inappropriate empiric antibiotic regimens after the causative pathogen has been isolated does not si...
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Delay in initiating appropriate antibiotic treatment in patients with severe nosocomial pneumonia (SNP) is associated with a more unfavorable prognosis,1-6 longer hospital stays, and consequently higher healthcare costs. Moreover, in the context of ventilator-associated pneumonia (VAP), changing inappropriate empiric antibiotic regimens after the causative pathogen has been isolated does not si...
متن کاملBiopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 3. Tobramycin.
The aim of this study was to determine the biopharmaceutical characteristics of tobramycin (TOB) after nebulization in rats. TOB was administered by intravenous (i.v.) bolus or intratracheal nebulization (3 mg · kg(-1)), and concentrations were determined in plasma and epithelial lining fluid (ELF) by liquid chromatography-tandem mass spectrometry. The ratio of the TOB concentration in ELF to t...
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ژورنال
عنوان ژورنال: Journal of Acute Disease
سال: 2012
ISSN: 2221-6189
DOI: 10.1016/s2221-6189(13)60004-9