Severe malaria, artesunate and haemolysis

Severe malaria, artesunate and haemolysis.

on two occasions, and the dose was adjusted accordingly a few times. He presented 2 weeks later with worsening symptoms of the right knee, including redness, swelling and pain. He was switched to 10 mg/kg telavancin intravenously every 24 h and rifampicin was continued. The MIC of telavancin was 0.25 mg/L. During the 6 week therapy with telavancin, the patient showed rapid improvement of sympto...

Severe Malaria and Artesunate Treatment, Norway

To the Editor: Approximately 8,000 cases of imported falciparum malaria are reported in Europe each year (1). In a study from Belgium of 1,743 persons with fever acquired in the Tropics, only falciparum malaria resulted in deaths (2). Until recently, the standard treatment of severe malaria was intravenous quinine (3). Frequent adverse effects, however, and reports of limited clinical effi cacy...

Artesunate Dosing in Severe Falciparum Malaria

TO THE EDITOR—In the past 6 years the largest ever randomized controlled trials in severe falciparum malaria have been reported [1, 2]. Compared with quinine, parenteral artesunate reduced mortality by 22.5% (from 10.9% to 8.5%) in African children (N = 5425) and by 35% (from 22% to 15%) in Southeast Asian patients (N = 1461, of whom 202 were children). The artesunate dose evaluated in the AQUA...

Artesunate versus quinine for treating severe malaria.

BACKGROUND Severe malaria results in over a million deaths every year, most of them in children aged under five years and living in sub-Saharan Africa. This review examines whether treatment with artesunate, instead of the standard treatment quinine, would result in fewer deaths and better treatment outcomes. OBJECTIVES To compare artesunate with quinine for treating severe malaria. SEARCH ...

Artesunate v. quinine for severe malaria.