Severe Anaemia during Natalizumab Treatment: Case Presentation with Literature Review

Progressive multifocal leukoencephalopathy is the most common serious complication related to natalizumab. However, haematological complications are very uncommon during treatment with Here we reported case of an 18-year-old man a 4-year history relapsing-re- mitting multiple sclerosis. He was treated firstly by Teriflunomide for 1 year, but he presented relapses and his MRI shows new contrast-enhancing lesions. Therefore, decided switch from Natalizumab. The patient profound anaemia after 16th infusions patient’s hemoglobin 3.2 g/dL lower blood reticulocyte value. After red cell transfusions cessation Natalizumab, resolved. Natalizumab changed anti-CD20 monoclonal antibody. had stable course sclerosis at 13 months initiation Rituximab. We should alert clinicians be aware possibility