Severe ABO hemolytic disease of newborn with a positive direct antiglobulin test

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Direct antiglobulin reaction in ABO-haemolytic disease of the newborn.

The minimum number of IgG anti-A (or anti-B) molecules detectable on A or B red cells by the antiglobulin reaction was found to be the same-that is, about 150 molecules per red cell-with newborn as with adult cells. Furthermore, the ratio of anti-IgG bound to IgG anti-A (or anti-B) molecules was the same whether the anti-A (or anti-B) molecules were present on newborn or on adult cells and was ...

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ABO Hemolytic Disease Leading to Hyperbilirubinemia in Term Newborns: Value of Immunohematological Tests

Introduction ABO hemolytic disease of the newborn is most common cause of neonatal jaundice; previous studies have shown a poor correlation between serologic tests and clinical course in affected infants. The aim of this study was to identify the value of direct and indirect Coombs’ immunohematological tests, to identify the incidence of hemolytic disease in newborns (ABO-HDN). Methods : This  ...

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Direct antiglobulin ("Coombs") test-negative autoimmune hemolytic anemia: a review.

We have reviewed the literature to identify and characterize reports of warm-antibody type, autoimmune hemolytic anemia in which the standard direct antiglobulin reaction was negative but a confirmatory test indicated that the red cells were opsonized with antibody. Three principal reasons account for the absence of a positive direct antiglobulin test in these cases: a) IgG sensitization below ...

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Positive direct antiglobulin test with Unasyn--a case report.

A 56-year-old Chinese lady with valvular heart disease and atrial fibrillation was referred to us from a private hospital for further management of autoimmune haemolytic anaemia. Physical examination and laboratory investigations did not support the diagnosis of haemolytic anaemia. However, direct antiglobulin test (DAT) was strongly positive with anti-IgG and negative with anti-C3d. There was ...

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[Hemolytic disease of newborn due to ABO incompatibility].

Hemolytic disease of newborn due to ABO-incompatibility is the most common cause of hemolytic diseases of newborns, its occur due to ABO blood group incompatibility between the mother and infant. The aim of study is to identify the incidence and severity of jaundice in patients with ABO incompatibility. Fifty four babies with ABO incompatibility admitted to AlKhansah maternity and children teac...

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ژورنال

عنوان ژورنال: Indian Journal of Pathology and Microbiology

سال: 2009

ISSN: 0377-4929

DOI: 10.4103/0377-4929.48958