Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity

Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity

The tissue-resident macrophages of barrier organs constitute the first line of defence against pathogens at the systemic interface with the ambient environment. In the lung, resident alveolarmacrophages (AMs)providea sentinel functionagainst inhaledpathogens.Bacterial constituents ligate Toll-like receptors (TLRs) onAMs, causingAMs to secrete proinflammatory cytokines that activate alveolar epi...

CHROMOSOMAL PROTEINS IN PULMONARY ALVEOLAR MACROPHAGES

In this study the nature of chromosomal proteins, his tones and nonhistone in resident alveolar macrophages was investigated in comparison to peritoneal neutrophils and calf thymus proteins. Cells were obtained by lavaging the lung and after purity determination they were subjected to fractional extraction procedures. Proteins were then analysed on SDS polyacrylamide gels and densitometric...

Alveolar hypoxia, alveolar macrophages, and systemic inflammation

Diseases featuring abnormally low alveolar PO2 are frequently accompanied by systemic effects. The common presence of an underlying inflammatory component suggests that inflammation may contribute to the pathogenesis of the systemic effects of alveolar hypoxia. While the role of alveolar macrophages in the immune and defense functions of the lung has been long known, recent evidence indicates t...

Normal Human Alveolar Macrophages

Interleukin1 (IL1) is a mediator released by stimulated mononuclear phagocytes that is thought to play an important role in modulating T and B lymphocyte activation as well as in contributing to the febrile response and other inflammatory processes. Circulating mononuclear phagocytes, blood monocytes, readily release ILI when stimulated. However, the ability of lung mononuclear phagocytes, alve...

Alveolar Macrophages Transport Pathogens