Serum transfer of collagen arthritis to cyclosporin-treated, type II collagen tolerant rats.
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چکیده
منابع مشابه
Expression of Collagen Type II and Osteocalcin Genes in Mesenchymal Stem Cells from Rats Treated with Lead acetate II
Background: Lead is one of the sustainable metals with devastating effects on many tissues. This study, examined the adverse effect of lead poisoning on the gene expression of collagen type II and osteocalcin by mesenchymal stem cells (MSCs) cultured in chondrogenic and osteogenic media, respectively. Methods: We used 18 male Wistar rats, divided in 3 groups. In addition to libitum feed as the...
متن کاملSerum Transfer of Collagen - Induced Arthritis
In 1977, Trentham et al. (1) described a model of polyarthritis induced in rats by immunization with type II collagen. The lesions identified on histopathologic examination resembled those of human rheumatoid arthritis (RA) 1. In addition, the arthritis was associated with high levels of both cellular and humoral immunity to collagen (2). Since collagen-related autoimmunity has also been descri...
متن کاملHumoral and cellular sensitivity to collagen in type II collagen-induced arthritis in rats.
We have recently described a new animal model of arthritis induced by intradermal injection of a distinct type of collagen found in cartilage (type II collagen). Since immunologic sensitivity to collagen could play a role in the pathogenesis of this type II collagen-induced arthritis in rats, the ability of purified types of native collagens to induce cellular and humoral responses was quantifi...
متن کاملType II collagen-induced arthritis in rats. Passive transfer with serum and evidence that IgG anticollagen antibodies can cause arthritis
We have found that serum from rats with type II collagen-induced arthritis, when fractionated with 50% ammonium sulfate and concentrated, would transfer arthritis to nonimmunized recipients. The arthritis in recipients developed within 18-72 h and displayed all of the major histopathologic characteristics of the early lesion in immunized animals but was transient and less severe. Although consi...
متن کاملParadoxical effects of cyclosporin A on collagen arthritis in rats
The effect of the immunosuppressive agent cyclosporin A (CS-A) on collagen arthritis in Sprague-Dawley rats is investigated. A 14-d course of CS-A treatment at doses of 15 mg/kg per day or more, begun on the same day as type II collagen immunization, suppressed the development of arthritis as well as humoral and delayed-type hypersensitivity (DTH) skin test responses to type II collagen, possib...
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ژورنال
عنوان ژورنال: Orthopedics & Traumatology
سال: 1985
ISSN: 1349-4333,0037-1033
DOI: 10.5035/nishiseisai.34.595