منابع مشابه
Serum thymulin in human zinc deficiency.
The activity of thymulin (a thymic hormone) is dependent on the presence of zinc in the molecule. We assayed serum thymulin activity in three models of mildly zinc-deficient (ZD) human subjects before and after zinc supplementation: (a) two human volunteers in whom a specific and mild zinc deficiency was induced by dietary means; (b) six mildly ZD adult sickle cell anemia (SCA) subjects; and (c...
متن کاملInteractions Between Zinc and Thymulin
Thymulin (formerly called "Facteur Thymique Sérique or FTS) is a metallopeptidic hormone selectively produced by thymic epithelial cells (TEC) and known to induce intra and extra-thymic T cell differentiation. It was initially isolated from porcine serum and shown to be present in calf thymus extract. Its amino-acid sequence was determined (<Glu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn). It is a nonapep...
متن کاملZinc Deficiency in Human Subjects
Zinc Deficiency in Human Subjects is a 268-page book detailing the proceedings of an international symposium held in Ankara, Turkey, in April 1982. Volume 129 in the series, Progress in Clinical and Biological Research, the book details varied original scientific research on zinc deficiency done primarily in Turkey. Ananda Prasad, the first to document zinc deficiency in humans, outlines the hi...
متن کاملZinc Deficiency in Human Health
Zinc exposure is receiving increasing attention as a public health problem because of the U-shaped dose-response curve in which adverse health effects are associated with the presence of either too little or too much zinc in the vulnerable tissues or organs. The growing scientific interest and research have led to a paradigm shift in terms of which arm of the U-curve should be of most concern t...
متن کاملThymulin gene therapy prevents the reduction in circulating gonadotropins induced by thymulin deficiency in mice.
Integrity of the thymus during perinatal life is necessary for a proper maturation of the pituitary-gonadal axis in mice and other mammalian species. Thus congenitally athymic (nude) female mice show significantly reduced levels of circulating gonadotropins, a fact that seems to be causally related to a number of reproductive derangements described in these mutants. Interestingly, a number of i...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1988
ISSN: 0021-9738
DOI: 10.1172/jci113717