Serum Levels of the Adipokine FGF21 Depend on Renal Function
نویسندگان
چکیده
منابع مشابه
Serum Levels of the Adipokine FGF21 Depend on Renal Function
OBJECTIVE To investigate renal elimination of the adipokine fibroblast growth factor 21 (FGF21) by determining circulating FGF21 levels in patients on chronic hemodialysis (CD) as compared with control subjects with a glomerular filtration rate (GFR) >50 ml/min. RESEARCH DESIGN AND METHODS FGF21 was determined by enzyme-linked immunosorbent assay in control (n = 60) and CD (n = 60) patients a...
متن کاملSerum Levels of the Adipokine Progranulin Depend on Renal Function
OBJECTIVE Progranulin has recently been introduced as a novel adipokine inducing insulin resistance and obesity. In the current study, we investigated renal elimination, as well as association of the adipokine with markers of the metabolic syndrome. RESEARCH DESIGN AND METHODS Progranulin serum levels were quantified by enzyme-linked immunosorbent assay and correlated to anthropometric and bi...
متن کاملComment on: Richter et al. Serum Levels of the Adipokine Progranulin Depend on Renal Function. Diabetes Care 2013;36:410–414
R ichter et al. (1) report an association between serum levels of the adipokine progranulin and chronic kidney disease (CKD) and demonstrate higher progranulin levels with deteriorating renal function—the highest progranulin levels being observed in stage 5 of CKD. The authors conclude that impaired renal clearance might account for this association and that their results are compatible with th...
متن کاملSerum Levels of the Adipokine Chemerin in Relation to Renal Function
OBJECTIVE To investigate serum levels of the adipokine chemerin in patients on chronic hemodialysis (CD) as compared with control patients with a glomerular filtration rate (GFR) >50 ml/min. RESEARCH DESIGN AND METHODS Chemerin was quantified by ELISA in control patients (n = 60) and CD patients (n = 60) and correlated with clinical and biochemical measures of renal function, glucose, and lip...
متن کاملResponse to Comment on: Richter et al. Serum Levels of the Adipokine Progranulin Depend on Renal Function. Diabetes Care 2013;36:410–414
W e thank Dr. Triebel (1) for his comments regarding our recent findings on circulating progranulin in relation to renal function. Concerning our data on progranulin in spot urine, the adipokine was quantified in samples of 29 sex-matched patients of each chronic kidney disease stage (N 5 145), which were randomly assigned using SPSS software version 18.0 (IBM, Armonk, NY). In these experiments...
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ژورنال
عنوان ژورنال: Diabetes Care
سال: 2008
ISSN: 0149-5992,1935-5548
DOI: 10.2337/dc08-1054