Serum Levels of Adipokine Retinol-Binding Protein-4 in Relation to Renal Function

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Serum levels of adipokine retinol-binding protein-4 in relation to renal function: response to Ziegelmeier et al.

OBJECTIVE Retinol-binding protein (RBP)-4 was recently identified as an adipokine that induces insulin resistance. In the current study, we investigated RBP-4 serum levels in diabetic and nondiabetic patients on chronic hemodialysis (CD) compared with control subjects with a glomerular filtration rate >50 ml/min. The majority of the diabetic subjects used oral hypoglycemic agents or insulin. ...

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Evidence That Kidney Function but Not Type 2 Diabetes Determines Retinol-Binding Protein 4 Serum Levels

OBJECTIVE It has been suggested that retinol-binding protein 4 (RBP4) links adiposity, insulin resistance, and type 2 diabetes. However, circulating RBP4 levels are also affected by kidney function. Therefore, the aim of this study was to test whether RBP4 serum levels are primarily associated with kidney function or type 2 diabetes. RESEARCH DESIGN AND METHODS RBP4 serum concentration was de...

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ژورنال

عنوان ژورنال: Diabetes Care

سال: 2007

ISSN: 0149-5992,1935-5548

DOI: 10.2337/dc07-0275