Serum HER2 extra-cellular domain, S100ß and CA 15-3 levels are independent prognostic factors in metastatic breast cancer patients
نویسندگان
چکیده
منابع مشابه
Prognostic significance of serum HER2 and CA 15-3 at the time of diagnosis of metastatic breast cancer.
BACKGROUND Serum HER2 testing allows the determination of real-time HER2 status during clinical course. The aim of this investigation was: (1) to study the prognostic significance of serum HER2 at the time of first diagnosis of metastatic breast cancer and (2) to evaluate its relationship to CA15-3 which is a surrogate marker for tumor load. MATERIALS AND METHODS Serum samples of 120 breast c...
متن کاملPredicting tissue HER2 status using serum HER2 levels in patients with metastatic breast cancer.
BACKGROUND Immunohistochemistry (IHC) and fluorescent in situ hybridization (FISH) are reliable ways to identify overexpression or amplification of the HER-2/neu (HER2, symbol ERBB2) gene, but each technique requires a high-quality tissue sample, which may not be available. We investigated whether serum concentrations of the HER2 extracellular domain (ECD) can be used as an alternative to tissu...
متن کاملBaseline serum NTx levels are prognostic in metastatic breast cancer patients with bone-only metastasis.
BACKGROUND There is significant heterogeneity in survival of patients with metastatic breast cancer who have bone-only metastasis. We studied the correlation of serum N-telopeptide (NTx), a marker of bone resorption, and its correlation with clinical outcomes in patients with metastatic breast cancer with bone-only or bone plus soft tissue metastasis. PATIENTS AND METHODS Serum was taken from...
متن کاملevaluation of prognostic factors in patients with metastatic breast cancer
abstract purpose: metastatic breast cancer has remained as an incurable disease. the main objectives of treatments include alleviating of symptoms, delaying disease progression and increasing survival without any adverse effect on the quality of life. the main purpose of this study was to investigate the effects of some clinocopathological factors on the survival of patients with metastatic bre...
متن کاملRelationship of serum HER-2/neu and serum CA 15-3 in patients with metastatic breast cancer.
BACKGROUND Serum HER-2/neu antigen concentrations have been reported to correlate with increased tumor volume in patients with breast cancer. We measured serum CA 15-3, a surrogate marker of disease burden, and correlated serum CA 15-3 with serum HER-2/neu and analyzed the association of both markers with clinical outcomes. METHODS Pretreatment serum samples from 566 patients were retrospecti...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Cancer
سال: 2016
ISSN: 1471-2407
DOI: 10.1186/s12885-016-2448-1