Serum Globulins as Mediators of Pathological Changes of Capillary Permeability

The Presence of Two Permeability Globulins

Among the substances in mammalian sera that increase vascular permeability under experimental conditions are two globulins, the permeability globulins. The first, kallikrein, was originally described by Frey (2); the second, PF/dil, was first described by Mackay, Miles, Shachter, and Wilhelm (3). The permeability-increasing activity of kallikrein appears to be mediated through the enzymatic gen...

Changes in Serum Alpha-2 Globulins in Reticuloses.

The total concentrations of alpha(2) globulin and two of its components, haptoglobin and caeruloplasmin, have been determined in the sera from 78 patients with primary malignant diseases of lympho-reticular tissue (reticuloses). The total alpha(2) globulin fraction was significantly raised only in Hodgkin's disease. The serum haptoglobin was also significantly increased in Hodgkin's disease and...

Changes in permeability of the alveolar-capillary barrier in firefighters.

The effect on alveolar-capillary barrier permeability of chronic exposure to a smoke produced by the partial combusion of diesel oil, paraffin, and wood was examined. An index of permeability was determined from the rate of transfer from the lung into the blood of the hydrophilic, labelled chelate 99mTc diethylene triamine penta-acetate (MW 492 dalton). The results of this test were expressed a...

Changes in lung capillary permeability in renal failure.

Excess fluid in the lung can be quantified in chronic dialysis patients by using the double indicator dilution technique. The lung capillaries show an increased permeability to sodium when these patents develop pulmonary oedema.

The Alleged Transformation of Serum Albumin into Serum Globulins.