Serum cystatin C is not a better marker of creatinine or digoxin clearance than serum creatinine
نویسندگان
چکیده
منابع مشابه
Serum cystatin C is a better marker of topotecan clearance than serum creatinine.
PURPOSE To evaluate plasma cystatin level as a covariate to predict topotecan pharmacokinetics. Cystatin C, a member of the cystatin superfamily of cysteine proteinase inhibitors, has been recently proposed as an alternative endogenous marker of glomerular filtration. Renal function is known as a key factor of topotecan clearance. EXPERIMENTAL DESIGN Data were obtained from 59 patients who un...
متن کاملRelationship between Serum Creatinine, Cystatin-C and Creatinine Clearance in Chronic Kidney Disease
Recommendations for laboratory diagnosis and monitoring of chronic kidney disease (CKD) state the use of both serum creatinine and cystatin-C in various clinical situations. The relationship of these markers to estimated glomerular filtration rate (eGFR) is found to be different in different populations. In India the routine reporting of eGFR is yet to commence. Meanwhile, the utility of these ...
متن کاملSerum cystatin C measured by automated immunoassay: a more sensitive marker of changes in GFR than serum creatinine.
Serum cystatin C has been suggested as a new marker of GFR. For the introduction of this marker into clinical use a rapid and automated method is required. We have developed and validated an assay for serum cystatin C using latex particle-enhanced immunoturbidimetry. Intra- and inter-assay precision were < 3% and < 5% across the assay range. Analytical recovery was 93 +/- 3.8% and no lack of pa...
متن کاملSerum cystatin C, determined by a rapid, automated particle-enhanced turbidimetric method, is a better marker than serum creatinine for glomerular filtration rate.
We describe a fully automated particle-enhanced turbidimetric assay for cystatin C in undiluted serum and EDTA-plasma. The throughput is 90 samples per hour and urgent samples can be analyzed in 7 min. The assay range (0.4-14.1 mg/L) covers the concentration range in health and disease. The within- and between-run imprecision is 0.9% and 2.2%, respectively. Analytical recovery of additions of r...
متن کاملSerum cystatin C predicts vancomycin trough levels better than serum creatinine in hospitalized patients: a cohort study
INTRODUCTION Serum cystatin C can improve glomerular filtration rate (GFR) estimation over creatinine alone, but whether this translates into clinically relevant improvements in drug dosing is unclear. METHODS This prospective cohort study enrolled adults receiving scheduled intravenous vancomycin while hospitalized at the Mayo Clinic in 2012. Vancomycin dosing was based on weight, serum crea...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2002
ISSN: 0306-5251
DOI: 10.1046/j.1365-2125.2002.01549.x