Serum CXCL9 and CCL17 as biomarkers of declining pulmonary function in chronic bird-related hypersensitivity pneumonitis
نویسندگان
چکیده
منابع مشابه
Higher serum CCL17 may be a promising predictor of acute exacerbations in chronic hypersensitivity pneumonitis
BACKGROUND Recent research has suggested that the Th1 and Th2 chemokine/cytokine axis contributes to the development of chronic hypersensitivity pneumonitis (HP). Acute exacerbations (AE) are significant factors in the prognosis of chronic HP. Little is known, however, about these biomarkers in association with AE in chronic HP patients. METHODS Fifty-six patients with chronic HP were evaluat...
متن کاملQuantifying serum antibody in bird fanciers' hypersensitivity pneumonitis
BACKGROUND Detecting serum antibody against inhaled antigens is an important diagnostic adjunct for hypersensitivity pneumonitis (HP). We sought to validate a quantitative fluorimetric assay testing serum from bird fanciers. METHODS Antibody activity was assessed in bird fanciers and control subjects using various avian antigens and serological methods, and the titer was compared with symptom...
متن کاملQuantifying Serum Antibody in Bird Fanciers ’ 1 Hypersensitivity Pneumonitis
24 Background 25 Detecting serum antibody against inhaled antigens is an important diagnostic adjunct for 26 hypersensitivity pneumonitis (HP). We sought to validate a quantitative fluorimetric 27 assay testing serum from bird fanciers. 28 Methods 29 Antibody activity was assessed in bird fanciers and control subjects using various avian 30 antigens and serological methods, and the titer was co...
متن کاملProtein antigen of bird-related hypersensitivity pneumonitis in pigeon serum and dropping
BACKGROUND Avian antigen is a common cause of hypersensitivity pneumonitis (HP). Inhalation challenge with pigeon serum and pigeon dropping extract (PDE) elicits a hypersensitivity reaction in patients with bird-related hypersensitivity pneumonitis (BRHP), but the antigenic components in these materials have yet to be fully elucidated. METHOD Pigeon serum, pigeon intestine homogenates, and PD...
متن کاملSeasonal variation of serum KL-6 and SP-D levels in bird-related hypersensitivity pneumonitis.
Bird-related hypersensitivity pneumonitis (HP) is an immunologically mediated lung disease induced by inhalation of bird dropping extracts and antigens in feathers (1). Environmental assessment and removal of the avian antigen are crucial in the management of bird-related HP. Measurement of serum Krebs von den Lungen-6 (KL-6) and surfactant protein D (SP-D) is widely accepted in Japan, as a dia...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2019
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0220462