Serum Colony-stimulating Activity of Dogs With Cyclic Neutropenia

Serum colony-stimulating activity of dogs with cyclic neutropenia.

Human cyclic neutropenia: urinary colony-stimulating factor and erythropoietin levels.

Daily levels of urinary colony-stimulating in the neutropenic period antecedent to factor (CSF) were measured in two pathe periodic reticulocytosis. These studies tients with cyclic neutropenia. The CSF are compatible with a negative feedback levels increased during the neutropenic system regulating both granulocytopoiesis period concomitant with the maximum and erythropoiesis. Whether the cycl...

Cyclic neutropenia: the relationship between urine granulocyte colony stimulating activity and neutrophil count.

Expression of receptors for granulocyte colony-stimulating factor on neutrophils from patients with severe congenital neutropenia and cyclic neutropenia.

We studied granulocyte colony-stimulating factor (G-CSF) binding sites on neutrophils from patients with severe congenital neutropenia (SCN; Kostmann-syndrome) and cyclic neutropenia (CN) during treatment with recombinant human (rh) G-CSF. G-CSF receptor expression was measured by scatchard analysis. Neutrophils from six healthy controls expressed between 480 and 1,210 binding sites per cell, w...

Increased serum levels of granulocyte colony-stimulating factor in patients with severe congenital neutropenia.

Severe congenital neutropenia (SCN), also known as Kostmann Syndrome, is characterized by a maturation arrest of myelopoiesis at the level of promyelocytes with absence of neutrophils in bone marrow (BM) and blood. Hypotheses of the pathophysiology of SCN include (1) defective production of granulocyte colony-stimulating factor (G-CSF), and/or (2) defective response to G-CSF. To exclude defecti...