Serum Calprotectin and B-cell activating factor are potential biomarkers for <i>Helicobacter pylori</i> infection

Humans always mount a robust immune response to the bacterial infection caused by Helicobacter pylori, which causes various gastrointestinal tract infections. Calprotectin (CALP) and B-Cell Activating Factor (BAFF) are inflammatory biomarkers having role in neutrophilic infection. The study was designed assess serum CALP BAFF as H. pylori peptic ulcer patients. current comprised 112 people, including 62 pylori-infected patients (34 men 28 women) who were clinically diagnosed with via testing positive for stool antigen test; they compared control group of 50 healthy people 16 age gender- matched level assayed using ELISA technique. biochemical parameters statistically between controls unpaired Man-Whitney U t-test Receiver Operating Characteristic (ROC) curve analysis. There significant elevation [116.4(120.7), p=0.0132] comparison [99.50(115.8)]. Similarly, there concentration [485.7(367.1), p=0.0014] [444.5(513.0)]. ROC analysis suggests reasonable (p=0.0135, p=0.0015) area under (0.6361, 0.6748), respectively. potent involved development etiology Serum levels could be used chronic inflammation induced pylori. can combined diagnose predict prognosis