Serum Amyloid A Protein, SAA

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Human serum amyloid A (SAA)

Serum amyloid A apol ipoprote in family consists of three members that in human beings are coded by different genes: SAA1, SAA2, and SAA4 (reviewed in 1-3). SAA1 and SAA2 are so-called acute phase isoforms. Their expression is increased in response to inflammation. SAA4 is a constitutive isoform, the expression of which does not change during an acute-phase response. In addition, one more relat...

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Factors Influencing Serum Amyloid Type A (Saa) Concentrations in Horses

The acute phase response (APR) is the reaction that occurs in animals in response to disturbances in hemostasis following tissue damage. In horses, the APR is manifested in a variety of pathological processes of various origins, such as infections caused by bacteria, viruses, parasites, arthritis, burns, chemicals, trauma surgery and stress. Acute phase proteins (APPs) are considered those prot...

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Some properties of antisera to serum amyloid A protein (SAA): inhibition of precipitation by complexing of SAA to albumin

Three potent rabbit antisera to human serum amyloid A protein (SAA) appear to be directed exclusibely to the carboxy terminal region not shared with the tissue amyloid A protein. Since binding to albumin completely blocks the reaction of these antisera with the antigen, and since SAA exists in serum complexed to albumin, the anti-SAA cannot be used to detect or quantitate this serum component. ...

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Heparan sulfate dissociates serum amyloid A (SAA) from acute-phase high-density lipoprotein, promoting SAA aggregation.

Inflammation-related (AA) amyloidosis is a severe clinical disorder characterized by the systemic deposition of the acute-phase reactant serum amyloid A (SAA). SAA is normally associated with the high-density lipoprotein (HDL) fraction in plasma, but under yet unclear circumstances, the apolipoprotein is converted into amyloid fibrils. AA amyloid and heparan sulfate (HS) display an intimate rel...

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Prognostic Importance of Monitoring Serum Amyloid a Protein (saa) in Patients with Cerebral Infarction

∑ Serum amyloid A protein (SAA) is an acute-phase plasma protein, which increases in response to tissue damage. The aim of the study was to investigate SAA in the blood of patients with cerebral infarction. Sixty subjects were studied, including 45 patients with cerebral infarction and 15 controls. SAA was determined using ELISA method on days 1, 3, 7 and 14 after ischemic stroke onset. SAA was...

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ژورنال

عنوان ژورنال: The Journal of Japan Atherosclerosis Society

سال: 1997

ISSN: 0386-2682,2185-8284

DOI: 10.5551/jat1973.24.9_431