Serum 25-Hydroxyvitamin D Immunoassays: Recommendations for Correct Clinical Interpretation
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چکیده
منابع مشابه
Serum 25-hydroxyvitamin D immunoassays: recommendations for correct clinical interpretation.
assay on the Roche Modular analyzer. They used clinical samples that were almost free of 25hydroxyvitamin D2 (25-OH-D2) ( 10 nmol/L) as confirmed by liquid chromatography–tandem mass spectrometry (LC-MS/MS) and found a good overall agreement between the results obtained with the Roche assay and those measured with the DiaSorin RIA and by LC-MS/MS. Although they acknowledged that the Roche assay...
متن کاملPerformance evaluation of two immunoassays for 25-hydroxyvitamin D
Although immunoassays in measuring 25-hydroxyvitamin D [25(OH)D] have been improved recently, relatively large differences are still seen between results of 25(OH)D measured by immunoassays and by liquid chromatography-tandem mass spectrometry (LC-MS/MS). In the present studies, we compared two immunoassays with LC-MS/MS for measuring 25(OH)D concentrations. Concentrations of 25-hydroxyvitamin ...
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BACKGROUND There is increasing evidence that vitamin D deficiency is common and has been associated with several non-bone related outcomes, including insulin resistance, type 2 diabetes and cardiovascular disease. The influences of gender, puberty, and adiposity on serum hydroxyvitamin D (25-OH-D) levels and the relationship between 25-OH-D and insulin resistance in obese children were studied....
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The unique cis-triene structure of vitamin D and related metabolites makes it susceptible to oxidation, ultraviolet (UV) light-induced conformational changes, heat-induced conformational changes, and attacks by free radicals. Vitamin D(2) is much less bioactive than vitamin D(3) in humans. Metabolic activation and inactivation of vitamin D are well characterized and result in a plethora of meta...
متن کاملOptimal serum 25-hydroxyvitamin D levels for multiple health outcomes.
Recent evidence suggests that higher vitamin D intakes beyond current recommendations may be associated with better health outcomes. In this chapter, evidence is summarized from different studies that evaluate threshold levels for serum 25(OH)D levels in relation to bone mineral density (BMD), lower extremity function, dental health, risk of falls, admission to nursing home, fractures, cancer p...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2009
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2008.122952