Serotype distribution of invasive, non-invasive and carried Streptococcus pneumoniae in Malaysia: a meta-analysis

Abstract Background Pneumococcal pneumonia is the leading cause of under-five mortality globally. The surveillance pneumococcal serotypes therefore vital for informing vaccination policy and programmes. conjugate vaccines (PCVs) have been available as an option in private healthcare setting beginning December 2020, PCV10 was incorporated part routine national immunisation programme (NIP) Malaysia. We searched existing literature on serotype distribution across Malaysia to provide overall view this before implementation PCV10. Methods Online databases (PubMed, Ovid MEDLINE Scopus), reference lists articles identified, grey (Malaysian Ministry Health website, WHO website) were systematically relevant up 10th November 2020. No lower date limit set maximise number target reports returned. Results split by age categories, including ≤5 years, > 5 years unreported those that did not specify. search returned 18 results, with a total 2040 isolates. most common all disease types 19F ( n = 313, 15.3% [95%CI: 13.8–17.0]), 23F 166, 8.1% 7.0–9.4]), 14 (n 6B 163, 8.0% 6.9–9.2]) 19A 138, 6.8% 5.8–7.9]). Conclusion Four isolate sources are covered PCV10, while PCV13 provides greater coverage comparison There still need studies, particularly investigating children under age, monitor vaccine effectiveness population dynamic following into immunisation.