Serotonin syndrome in the perioperative period

Serotonin syndrome with perioperative oxycodone and pregabalin.

Potassium in the perioperative period.

Potassium ions play a vital role at a cellular level. These ions are actively transported into cells, causing an electrical imbalance and a build up of potential energy. When this energy is released following correct stimulation, the cells perform their designated functions. When these functions relate mainly to the heart and skeletal muscles, nerve and renal activity, the importance of potassi...

Epigenetics in the perioperative period.

The perioperative period is characterized by profound changes in the body's homoeostatic processes. This review seeks to address whether epigenetic mechanisms may influence an individual's reaction to surgery and anaesthesia. Evidence from animal and human studies suggests that epigenetic mechanisms can explain many facets of susceptibility to acute and chronic pain, making them potential thera...

The Perioperative Period

Therefore this chapter will first focus on aspects of acid-base physiology that are relevant to most anesthesiologists. It will become clear that acid-base disorders may have a major clinical impact both on the patient scheduled for anesthesia and anesthetic drugs. But even more importantly, many clinical interventions by anesthesiologists may actually profoundly influence [H+] itself. The impo...

Anaphylaxis during the perioperative period.

Anesthesiologists use a myriad of drugs during the provision of an anesthetic. Many of these drugs have side effects that are dose related, and some lead to severe immune-mediated adverse reactions. Anaphylaxis is the most severe immune-mediated reaction; it generally occurs on reexposure to a specific antigen and requires the release of proinflammatory mediators. Anaphylactoid reactions occur ...