Serotonin Receptors Regulate Inflammatory Response in Experimental Colitis

(5-ht)-3 receptors are involved in producing anti-inflammatory effects of tropisetron on experimental tnbs-induced colitis in rat

Serotonin has a key role in pathogenesis of experimental colitis.

BACKGROUND & AIMS Mucosal changes in inflammatory bowel disease are characterized by ulcerative lesions accompanied by a prominent infiltrate of immune cells as well as alteration in serotonin (5-hydroxytryptamine [5-HT])-producing enterochromaffin cells. We investigated the role of 5-HT in colonic inflammation in mice. METHODS Colitis was induced with dextran sulfate sodium or dinitrobenzene...

Contribution of adenosine A2B receptors to inflammatory parameters of experimental colitis.

Inflammatory diseases influence tissue metabolism, significantly altering the profile of extracellular adenine nucleotides. A number of studies have suggested that adenosine (Ado) may function as an endogenously generated anti-inflammatory molecule. Given the central role of intestinal epithelial cells to the development of colitis, we hypothesized that specific Ado receptors would contribute t...

Role of T Cells in the Inflammatory Response of Experimental Colitis Mice

Dimethyl Fumarate Reduces Inflammatory Responses in Experimental Colitis.

BACKGROUND AND AIMS Fumaric acid esters have been proven to be effective for the systemic treatment of psoriasis and multiple sclerosis. We aimed to develop a new treatment for colitis. METHODS We investigated the effect of dimethylfumarate [DMF, 10-30-100mg/kg] on an experimental model of colitis induced by dinitrobenzene sulphuric acid [DNBS]. We also evaluated the therapeutic activity of 7...