Serotonin-induced inhibition of locomotor rhythm of the rat isolated spinal cord is mediated by the 5–HT1 receptor class
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منابع مشابه
Effects of noradrenaline on locomotor rhythm-generating networks in the isolated neonatal rat spinal cord.
We have studied the effects of the biogenic amine noradrenaline (NA) on motor activity in the isolated neonatal rat spinal cord. The motor output was recorded with suction electrodes from the lumbar ventral roots. When applied on its own, NA (0.5-50 microM) elicited either no measurable root activity, or activity of a highly variable nature. When present, the NA-induced activity consisted of ei...
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15 صفحه اولNMDA receptor-mediated oscillatory activity in the neonatal rat spinal cord is serotonin dependent.
The effect of serotonin (5-HT) receptor blockade on rhythmic network activity and on N-methyl--aspartate (NMDA) receptor-induced membrane voltage oscillations was examined using an in vitro neonatal rat spinal cord preparation. Pharmacologically induced rhythmic hindlimb activity, monitored via flexor and extensor electroneurograms or ventral root recordings, was abolished by 5-HT receptor anta...
متن کاملRAPID COMMUNICATION NMDA Receptor-Mediated Oscillatory Activity in the Neonatal Rat Spinal Cord Is Serotonin Dependent
MacLean, Jason N., Kristine C. Cowley, and Brian J. Schmidt. spinal cats reverses perturbations of the locomotor pattern NMDA receptor-mediated oscillatory activity in the neonatal rat produced by 5-HT agonists (Barbeau and Rossignol 1990), spinal cord is serotonin dependent. J. Neurophysiol. 79: 2804– it remains to be shown whether endogenous 5-HT receptor 2808, 1998. The effect of serotonin (...
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ژورنال
عنوان ژورنال: Proceedings of the Royal Society of London. Series B: Biological Sciences
سال: 1998
ISSN: 0962-8452,1471-2954
DOI: 10.1098/rspb.1998.0542