Serotonin and beyond: therapeutics for major depression
نویسندگان
چکیده
منابع مشابه
Serotonin and beyond: therapeutics for major depression.
The serotonin (5-HT, 5-hydroxytryptamine) system has been implicated in the pathogenesis of major depressive disorder (MDD). The case for its contribution to the therapeutic efficacy of a wide variety of antidepressant treatments is, however, much stronger. All antidepressant strategies have been shown to enhance 5-HT transmission in the brain of laboratory animals. Catecholamines, norepinephri...
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Background: several studies have explored the relationship between blood lipid levels and depressive disorders. Specific studies reported an association between lower serum cholesterol and depressive disorder, while some other studies no connection. The aim of this study was to evaluate the relationship of serum lipid profiles and serum serotonin with depressive disorder. Methods: In the prese...
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Major depression is a common psychiatric disorder with considerable associated morbidity and mortality. Investigations to understand the causes of depression and how it can be more effectively treated are high priority. The serotonergic system has been implicated in the aetiology and treatment of depression by a wealth of preclinical and clinical evidence. This includes findings that drugs incr...
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ژورنال
عنوان ژورنال: Philosophical Transactions of the Royal Society B: Biological Sciences
سال: 2013
ISSN: 0962-8436,1471-2970
DOI: 10.1098/rstb.2012.0536