منابع مشابه
Serotonin 1A and Serotonin 4 Receptors: Essential Mediators of the Neurogenic and Behavioral Actions of Antidepressants.
Selective serotonin reuptake inhibitors are the mostly widely used treatment for major depressive disorders and also are prescribed for several anxiety disorders. However, similar to most antidepressants, selective serotonin reuptake inhibitors suffer from two major problems: They only show beneficial effects after 2 to 4 weeks and only about 33% of patients show remission to first-line treatme...
متن کاملSerotonin 1A receptors alter expression of movement representations.
Serotonin has a myriad of central functions involving mood, appetite, sleep, and memory and while its release within the spinal cord is particularly important for generating movement, the corresponding role on cortical movement representations (motor maps) is unknown. Using adult rats we determined that pharmacological depletion of serotonin (5-HT) via intracerebroventricular administration of ...
متن کاملSolubilization of human serotonin 1A receptors expressed in neuronal cells.
The serotonin 1A receptor is an important member of the G-protein coupled receptor family, and is involved in a variety of cognitive, behavioral, and developmental functions. None of the subtypes of G-protein coupled serotonin receptors have yet been purified to homogeneity from natural sources. We report here, for the first time, the solubilization of human serotonin(1A) receptors stably expre...
متن کاملModulation of anxiety by cortical serotonin 1A receptors
Serotonin (5-HT) plays an important role in the modulation of behavior across animal species. The serotonin 1A receptor (Htr1a) is an inhibitory G-protein coupled receptor that is expressed both on serotonin and non-serotonin neurons in mammals. Mice lacking Htr1a show increased anxiety behavior suggesting that its activation by serotonin has an anxiolytic effect. This outcome can be mediated b...
متن کاملSerotonin receptors.
2. Classification of Serotonin Receptors 1625 2.1. Gq/11-Coupled Receptor Types 1626 2.1.1. The 5-HT2A Receptor 1626 2.1.2. The 5-HT2B Receptor 1627 2.1.3. The 5-HT2C Receptor 1628 2.2. Gs-Coupled Receptor Types 1628 2.2.1. The 5-HT4 Receptor 1629 2.2.2. The 5-HT6 Receptor 1629 2.2.3. The 5-HT7 Receptor 1629 2.3. Gi/o-Coupled Receptor Types 1630 2.3.1. The 5-HT1A Receptor 1630 2.3.2. The 5-HT1B...
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ژورنال
عنوان ژورنال: The Neuroscientist
سال: 2014
ISSN: 1073-8584,1089-4098
DOI: 10.1177/1073858414561303