Serological profile and interpretation of different hepatitis B virus marker

Hepatitis B virus (HBV) infections are a global public health problem. Chronic hepatitis (CHB) infection is associated with an increased risk of cirrhosis, hepatic decompensation and hepatocellular carcinoma (HCC). In virus-infected liver cells, HBsAg produced in excess secreted into the blood, where it serves as marker for active infectivity. Currently, recombinant used HBV vaccination, development antibody to typically protective immunity. The likelihood developing CHB related age at which acquired; being lowest adults >90% neonates whose mothers e antigen positive. During infection, Different markers detectable blood. Presence this serum carry importance diagnosing stage illness. Most common clinical significance is: HBsAg, HBeAg, anti-HBs, anti-HBe, Anti-HBcIgM, Anti HBc (total). This can be easily detected by different serological methods eg, ICT, ELISA, CMIA, MEIA. We have studied records parameters, advised earlier physicians BIHS General Hospital. Last year, about 1,364 patients were tested markers: surface its (anti-HBs); e-antigen (anti-HBe); core (anti-HBc)