Serious infections in JIA patients upon MTX, TFN inhibitors and combinations
نویسندگان
چکیده
منابع مشابه
Serious infections in JIA patients upon MTX, TFN inhibitors and combinations
Results A total of 3350 pts. with 5929 exposure years were identified in the German BIKER registry data base. First biologic was ETA in 1720 and ADA in 177 cases. 1353 patients were not exposed to biologics. 28 serious infections have been reported (4.7/1000 pt-years). MTX patients had 5 events, Etanercept patients 21 and patients with Adalimumab therapy 2 events.The serious infections were of ...
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Methotrexate (MTX) is an effective, relatively safe, and low-cost treatment for children with JIA, but its use is often limited by the occurrence of so called intolerance in a significant number of patients [1, 2]. Many JIA patients receive anti-emetics as a co-medication to prevent or treat MTXintolerance. In a recent review in this journal Falvey et al. concluded: “Co-medication with anti-eme...
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Purpose HLA class I-specific killer cell immunoglobulin-like receptors (KIR) gene and HLA gene combinations have been associated with autoimmune uveitis (e.g., birdshot chorioretinopathy (BCR) and Vogt-Koyanagi-Harada syndrome (VKH)). In oligoarticular juvenile idiopathic arthritis (JIA), uveitis is one of the most serious complications, affecting approximately 20% of patients. Multiple studies...
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ژورنال
عنوان ژورنال: Pediatric Rheumatology
سال: 2014
ISSN: 1546-0096
DOI: 10.1186/1546-0096-12-s1-o11