Serine Protease Inhibition by a Silanediol Peptidomimetic
نویسندگان
چکیده
منابع مشابه
Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic a,b-unsaturated esters
The proteolytic processing of polyproteins by the 3CL protease of severe acute respiratory syndrome coronavirus is essential for the viral propagation. A series of tripeptide a,b-unsaturated esters and ketomethylene isosteres, including AG7088, are synthesized and assayed to target the 3CL protease. Though AG7088 is inactive (IC50 > 100 lM), the ketomethylene isosteres and tripeptide a,b-unsatu...
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ژورنال
عنوان ژورنال: Organic Letters
سال: 2012
ISSN: 1523-7060,1523-7052
DOI: 10.1021/ol301933n