Serial quantitative neuroimaging of iron in the intracerebral hemorrhage pig model

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Neuroimaging in intracerebral hemorrhage.

I ntracerebral hemorrhage (ICH) is described as spontaneous extravasation of blood into the brain parenchyma. This clinical entity is present in 10% to 15% of all stroke cases 1 in the Western population, with reported incidence rates higher in Asia. 2–4 It is also associated with a higher mortality rate compared with either ischemic stroke (IS) or subarachnoid hemorrhage. 5 ICH is classified a...

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Quantitative Intracerebral Hemorrhage Localization.

BACKGROUND AND PURPOSE The location of intracerebral hemorrhage (ICH) is currently described in a qualitative way; we provide a quantitative framework for estimating ICH engagement and its relevance to stroke outcomes. METHODS We analyzed 111 patients with ICH from the Minimally Invasive Surgery Plus Recombinant-Tissue Plasminogen Activator for Intracerebral Evacuation (MISTIE) II clinical tr...

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Intracerebral hemorrhage in the iron-deficient rat.

BACKGROUND AND PURPOSE Iron contributes to brain injury after intracerebral hemorrhage (ICH). Because ICH may occur in the context of iron deficiency anemia (IDA), a common nutritional disorder, the purpose of this study was to determine whether IDA in rats affects brain edema, functional behavior, and changes in brain iron-handling proteins after ICH. METHODS Six-week-old male rats (n=75) we...

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Quantitative intracerebral brain hemorrhage analysis

In this paper a system for 3-D quantitative analysis of human spontaneous intracerebral brain hemorrhage (ICH) is described. The purpose of the developed system is to perform quantitative 3-D measurements of the parameters of ICH region and from computed tomography (CT) images. The measured parameter in this phase of the system development is volume of the hemorrhage region. The goal of the pro...

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Iron-related brain damage in patients with intracerebral hemorrhage.

BACKGROUND AND PURPOSE Iron plays a detrimental role after experimental intracerebral hemorrhage (ICH). This study investigates whether high-serum ferritin levels are associated with poor outcome in patients with ICH. METHODS We studied 92 consecutive patients with primary hemispheric ICH within the first 12 hours from onset of symptoms (median, 3.3 hours). National Institute of Health Stroke...

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ژورنال

عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism

سال: 2018

ISSN: 0271-678X,1559-7016

DOI: 10.1177/0271678x17751548