Sequestration of Toxic Oligomers by HspB1 as a Cytoprotective Mechanism
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چکیده
منابع مشابه
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Peptides and proteins can convert from their soluble forms into highly ordered fibrillar aggregates, giving rise to pathological conditions ranging from neurodegenerative disorders to systemic amyloidoses. It is increasingly recognized that protein oligomers forming early in the process of fibril aggregation represent the pathogenic species in protein deposition diseases. The N-terminal domain ...
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Dysregulated cholinergic signaling is an early hallmark of Alzheimer disease (AD), usually ascribed to degeneration of cholinergic neurons induced by the amyloid-β peptide (Aβ). It is now generally accepted that neuronal dysfunction and memory deficits in the early stages of AD are caused by the neuronal impact of soluble Aβ oligomers (AβOs). AβOs build up in AD brain and specifically attach to...
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Background: Cholinergic dysfunction is an early feature of Alzheimer’s disease (AD). Results: Soluble oligomers of the amyloid-β peptide (Aβ) bind to cholinergic neurons and inhibit choline acetyl transferase (ChAT) activity, before any cell death or lesion. Conclusion: ChAT inhibiton might impair acetylcholine production and cholinergic function in AD brains. Significance: This novel effect of...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2011
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.01187-10