Sequence Variation in PPARG May Underlie Differential Response to Troglitazone

Sequence variation in PPARG may underlie differential response to troglitazone.

Thiazolidinediones (TZDs) are peroxisome proliferator-activated receptor-gamma (PPARG) agonists used to treat type 2 diabetes. TZDs can also be used to reduce rates of type 2 diabetes in at-risk individuals. However, a large fraction of TZD-treated patients (30-40%) do not respond to TZD treatment with an improvement in insulin sensitivity (Si). We hypothesized that variation within the gene en...

Increased Frontal Response May Underlie Decreased Tinnitus Severity

OBJECTIVES The overall goal of the study was to identify functional and behavioral differences between individuals with higher tinnitus distress and individuals with lower tinnitus distress. Subsequent exploratory analyses were conducted to investigate the role physical activity may have on the observed results between high and low distress groups. The purpose of the experiment was to identify ...

Response to Horizontal gene transfer may explain variation in theta_s

In a short article submitted to ArXiv [1], Maddamsetti et al. argue that BLOCKIN BLOCKIN the variation in the neutral mutation rate among genes in Escherichia coli that BLOCKIN BLOCKIN we recently BLOCKIN BLOCKIN reported [2] might be explained by horizontal BLOCKIN BLOCKIN gene transfer BLOCKIN BLOCKIN (HGT). To BLOCKIN BLOCKIN support BLOCKIN BLOCKIN their BLOCKIN BLOCKIN argument they BLOCKI...

Variation in the response of barley cultivars to nirrogen fertilizer

Differential nuclear localization of complexes may underlie in vivo intrabody efficacy in Huntington's disease

Intrabodies offer attractive options for manipulating the protein misfolding that triggers neurodegenerative diseases. In Huntington's disease, where the expanded polyglutamine tract in the extreme N-terminal region of huntingtin exon1 misfolds, two lead intrabodies have been selected against an adjacent peptide, using slightly different approaches. Both are effective at preventing aggregation ...