SEQUENCE SLIDER: expanding polyalanine fragments for phasing with multiple side-chain hypotheses
نویسندگان
چکیده
منابع مشابه
Synthesis of dehydroalanine fragments as thiostrepton side chain mimetics.
Syntheses of dehydroalanine derivatives via a solid-support route, starting from selenocystein, and via conventional solution phase chemistry are described along with initial biological testing. The target compounds were designed as mimetics of the dehydroalanine side chain of the macrocyclic antibiotic thiostrepton that acts on the bacterial ribosome.
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ژورنال
عنوان ژورنال: Acta Crystallographica Section D Structural Biology
سال: 2020
ISSN: 2059-7983
DOI: 10.1107/s2059798320000339