Sequence homology between barley trypsin inhibitor and wheat α-amylase inhibitors
نویسندگان
چکیده
منابع مشابه
Barley ~-amylase/subtilisin Inhibitor. Ii. N-terminal Amino Acid Sequence and Homology with Inhibitors of the Soybean Trypsin Inhibitor (kunitz) Family
An inhibitor of barley malt :t-amylase 2 isolated from barley malt and a specific inhibitor of subtilisin isolated from barley have been sequenced by automatic Edman degradation. The sequence of the first 40 N-terminal amino acids is the same for both proteins. The sequence is: Ala-Asp-Pro-Pro-Pro-Val-His-Asp-Thr-Asp-Gly-HisGlu-Leu-Arg-Ala-Asp-Ala-Asn-Tyr-Tyr-Val-Leu-Ser-Ala-Asn-Arg-Ala-His-Gly...
متن کاملSignal peptide homology between the sweet protein thaumatin II and unrelated cereal alpha-amylase/trypsin inhibitors.
A cDNA clone (pUP-23) corresponding to a member of a protein family that includes inhibitors of trypsin and of heterologous alpha-amylases has been selected from a library derived from developing barley endosperm and its sequence has been determined. A stretch of 95 nucleotides that included the signal peptide and the first 8 residues of the mature protein was found to be homologous to an exact...
متن کاملNew alpha-amylase and trypsin inhibitors among the CM-proteins of barley (Hordeum vulgare).
Barley CM-proteins are a group of at least five salt-soluble components (CMa-e) that can be selectively extracted from endosperm with chloroform/methanol mixtures. N-terminal sequences of proteins CMa, CMb and CMc have been determined and found to be homologous to those previously determined for CMd and CMe, an observation which confirms that their structural genes are members of a dispersed mu...
متن کاملWheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4
Ingestion of wheat, barley, or rye triggers small intestinal inflammation in patients with celiac disease. Specifically, the storage proteins of these cereals (gluten) elicit an adaptive Th1-mediated immune response in individuals carrying HLA-DQ2 or HLA-DQ8 as major genetic predisposition. This well-defined role of adaptive immunity contrasts with an ill-defined component of innate immunity in...
متن کاملWheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor
The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters. Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4.
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1982
ISSN: 0014-5793
DOI: 10.1016/0014-5793(82)80066-5