Sequence dependent effects in methylphosphonate deoxyribonucleotide double and triple helical complexes
نویسندگان
چکیده
منابع مشابه
Sequence dependent effects in methylphosphonate deoxyribonucleotide double and triple helical complexes.
Deoxyribooligonucleotides containing 19 repeating bases of A, T or U were prepared with normal phosphodiester (dA19, dT19, dU19) or methylphosphonate (dA*19, dT*19, dU*19) linkages. Complexes of these strands have been investigated at 1:1 and 1:2 molar ratios (purine:pyrimidine) by thermal melting and gel electrophoresis. There are dramatic sequence dependent differences in stabilities of compl...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1990
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/18.12.3545