Septic Shock in Man

Intravenous isoprenaline in treatment of septic shock in man.

Intravenous isoprenaline was given to 10 patients in septic shock, of which occult myocardial failure was the main indication. Isoprenaline expedited recovery in cases of "benign hypotension," where kidney function paradoxically remained satisfactory at low systolic pressures, and was useful in cases of "cold hypotension" which were complicated by renal failure alone. No significant improvement...

Septic Shock

Pediatric severe sepsis and septic shock continue to be significant causes of childhood morbidity and mortality worldwide. The following review will highlight some of the controversies surrounding the consensus definitions. It will chronicle recent clinical and translational research, focusing on pediatric sepsis-specific challenges investigators face. It will also address the pathophysiology o...

Septic shock.

Septic shock, the most severe complication of sepsis, is a deadly disease. In recent years, exciting advances have been made in the understanding of its pathophysiology and treatment. Pathogens, via their microbial-associated molecular patterns, trigger sequential intracellular events in immune cells, epithelium, endothelium, and the neuroendocrine system. Proinflammatory mediators that contrib...

Septic Shock in Neonates

Vasopressin in septic shock

Vasopressin (also known as antidiuretic hormone) is a nonapeptide produced in the paraventricular and supraoptic nuclei of the hypothalamaus and released from the posterior pituitary. It has two distinct roles that underlie its two names. In health, its main effect is to act in the control of osmolarity. Stimulation of vasopressin receptors (V2) in the distal convoluted tubule of the kidney res...