منابع مشابه
Quantitative resuscitation in sepsis.
Severe sepsis and septic shock are significant sources of morbidity and mortality in the emergency department (ED), with in-hospital mortality rates from sepsis remaining virtually unchanged between 1970 and 2000. In 2001, Rivers and colleagues demonstrated a 16% absolute reduction in mortality in patients with severe sepsis treated with a protocol-driven resuscitation strategy aimed at hemodyn...
متن کاملHypertonic saline resuscitation in sepsis
The review by Oliveira and colleagues on the subject of hypertonic saline resuscitation in sepsis (included in the present issue) suggests possible benefits for hypertonic saline. There is a firm experimental basis for the actions of hypertonic saline/hyperoncotic solutions in hemorrhagic hypotension, which include expansion of blood volume, improvement in cardiac index, favorable modulation of...
متن کاملClinical review: Hypertonic saline resuscitation in sepsis
The present review discusses the hemodynamic effects of hypertonic saline in experimental shock and in patients with sepsis. We comment on the mechanisms of action of hypertonic saline, calling upon data in hemorrhagic and septic shock. Specific actions of hypertonic saline in severe sepsis and septic shock are highlighted. Data are available that support potential benefits of hypertonic saline...
متن کاملFluid Resuscitation in Sepsis: Reexamining the Paradigm
Sepsis results in widespread inflammatory responses altering homeostasis. Associated circulatory abnormalities (peripheral vasodilation, intravascular volume depletion, increased cellular metabolism, and myocardial depression) lead to an imbalance between oxygen delivery and demand, triggering end organ injury and failure. Fluid resuscitation is a key part of treatment, but there is little agre...
متن کاملA critique of fluid bolus resuscitation in severe sepsis
Resuscitation of septic patients by means of one or more fluid boluses is recommended by guidelines from multiple relevant organizations and as a component of surviving sepsis campaigns. The technique is considered a key and life-saving intervention during the initial treatment of severe sepsis in children and adults. Such recommendations, however, are only based on expert opinion and lack adeq...
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ژورنال
عنوان ژورنال: Clinics in Chest Medicine
سال: 2016
ISSN: 0272-5231
DOI: 10.1016/j.ccm.2016.01.007