Sensitizing tumor cells to radiation by targeting the heat shock response
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چکیده
منابع مشابه
Targeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors.
Novel classes of anticancer drugs, including proteasome inhibitors and Hsp90 inhibitors, potently induce heat shock proteins (Hsps). Because Hsps show antiapoptotic activities, we suggested that suppression of such induction may sensitize cancer cells to these drugs. Here, we knocked out the major heat shock transcription factor HSF-1 in several cancer cell lines using small interfering RNA and...
متن کاملThe heat-shock response.
PERSPECTIVES AND SUMMARY .............................................................. 1151 CHARACTERIZATION OF THE RESPONSE .................................................. 1153 Comparison: Different Organisms and Stages of Development ........................... 1153 The Proteins Induced by Heat .................................................................. 1155 RNAs Induced by Heat .....
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TNF-related apoptosis-inducing ligand (TRAIL) is a current focus for the development of new cancer therapies, because of its selective induction of apoptosis in cancer cells. TRAIL has previously been shown to be important for tumor cell clearance from the liver; however, many cancer cell lines show some resistance toward TRAIL, posing a problem for the future use of TRAIL therapies. In this st...
متن کاملRhoA Activation Sensitizes Cells to Proteotoxic Stimuli by Abrogating the HSF1-Dependent Heat Shock Response
BACKGROUND The heat shock response (HSR) is an ancient and highly conserved program of stress-induced gene expression, aimed at reestablishing protein homeostasis to preserve cellular fitness. Cells that fail to activate or maintain this protective response are hypersensitive to proteotoxic stress. The HSR is mediated by the heat shock transcription factor 1 (HSF1), which binds to conserved hea...
متن کاملLeukemic Cells as Correlated to Their Heat Response 70,000 Heat Shock Genes in Control or Heat Shock
The expression of the M, 70,000 heat shock protein (HSP-70) in heatresistant variants or heat-shocked cells has been correlated with devel opment of thermal resistance. In these studies polymerase chain reaction (PCR) was used to detect low levels of HSP-70 mRNA present in control, unheated cells to investigate the possibility of predicting the intrinsic heat response in various leukemic cells....
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ژورنال
عنوان ژورنال: Cancer Letters
سال: 2015
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2015.02.033