Semiquantitative analysis of hypothalamic damage on MRI predicts risk for hypothalamic obesity
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Semiquantitative analysis of hypothalamic damage on MRI predicts risk for hypothalamic obesity
OBJECTIVE Excessive weight gain frequently occurs in patients with hypothalamic tumors and lesions leading to hypothalamic obesity (HO). METHODS Digital brain magnetic resonance imaging (MRI) and clinical outcomes were studied retrospectively in a single center, including 45 children with postoperative lesions in the sellar region (41 craniopharyngiomas, 4 with Rathke's cleft cysts), ∼5 years...
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Obesity is a Health issue around the world. Obesity is not limited to body weight, generally associated with low grade inflammation and with a cluster of disorders generally referred to as "metabolic syndrome". Regarding obesity and relapse, long-term concentration was set on the hypothalamus. Most recently,obesity- Originated neuroinflammation has been shown to affect other brain str...
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Hypothalamic obesity (HO) occurs in patients with tumors and lesions in the medial hypothalamic region. Hypothalamic dysfunction can lead to hyperinsulinemia and leptin resistance. This review is focused on HO caused by craniopharyngiomas (CP), which are the most common childhood brain tumors of nonglial origin. Despite excellent overall survival rates, CP patients have substantially reduced qu...
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Obesity, defined as abnormal or excessive fat accumulation that may impair life quality, is one of the major public health problems worldwide. It results from an imbalance between food intake and energy expenditure. The control of energy balance in animals and humans is performed by the central nervous system (CNS) by means of neuroendocrine connections, in which circulating peripheral hormones...
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Craniopharyngiomas (CP) are epithelial neoplasms generally found in the area of the pituitary and hypothalamus. Despite benign histology, these tumors and/or their treatment often result in significant, debilitating disorders of endocrine, neurological, behavioral, and metabolic systems. Severe obesity is observed in a high percentage of patients with CP resulting in significant comorbidities a...
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ژورنال
عنوان ژورنال: Obesity
سال: 2015
ISSN: 1930-7381,1930-739X
DOI: 10.1002/oby.21067