منابع مشابه
Self-immolative aryl phthalate esters.
We report that aryl phthalate esters are robust self-immolative linkers. This linker is easy to conjugate and releases output phenols upon cleaving a fluoride-sensitive mask to yield a benign phthalic acid byproduct, making these linkers potentially useful as fluoride sensors and promising for use in biological and materials applications.
متن کاملSelf-immolative phthalate esters sensitive to hydrogen peroxide and light.
Self-immolative aryl phthalate esters were conjugated with cleavable masking groups sensitive to light and hydrogen peroxide. The phthalate linker releases the fluorescent dye 7-hydroxycoumarin upon exposure to light or H2O2, respectively, leading to an increase in fluorescence. The light-sensitive aryl phthalate ester is demonstrated as a pro-fluorophore in cultured S2 cells.
متن کاملSelf-immolative polymers.
The investigation of synthetic polymers for biological applications is increasing as assembly techniques for generating welldefined macromolecules from artificial building blocks become more sophisticated. Synthesis techniques have now evolved such that a wide variety of functional groups can be tolerated by polymerization catalysts, and a fascinating and diverse range of macromolecular and pol...
متن کاملExposure to phthalate esters.
The American Chemistry Council Phthalate Esters Panel read with great interest the paper by Blount et al. (1) regarding urinary levels of phthalate ester metabolites in a sample set of the Third National Health and Nutrition Examination Survey (NHANES III) population. We have known for some time of this research, and have provided whatever information and assistance we could to the Centers for ...
متن کاملTesticular effects of phthalate esters.
The testicular effects produced by di(2-ethylhexyl) phthalate (DEHP) in the rat, characterized by a decrease in the relative organ weight and histological changes in the seminiferous tubules, can also be produced by di-n-butyl, di-n-pentyl and di-n-hexyl phthalates. The corresponding monoesters of these compounds, formed in vivo as a result of the action of nonspecific esterases in the intestin...
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ژورنال
عنوان ژورنال: The Journal of Organic Chemistry
سال: 2012
ISSN: 0022-3263,1520-6904
DOI: 10.1021/jo301698v