Self-Assembly of a Ginkgo Oligomerization Domain Creates a Sub-10-nm Honeycomb Architecture on Carbon and Silicon Surfaces with Customizable Pores: Implications for Nanoelectronics, Biosensing, and Biocatalysis

Over the last decade, protein self-assembly techniques have been extensively studied and improved, enabling production of a wide range different nanometric patterns. However, most studies in this field depict thin self-assemblies few nanometers height, while precise grafting molecules on patterns remains challenging. We present here natural polymeric honeycomb organization based abilities Ginkgo biloba oligomerization domain. This architecture depicts 3D pores 5 nm diameter height 40 stacked proteins. Each has tunable N- C-terminal extensions located inside pore, allowing bindings ligands pore. The proof concept is illustrated by distinctive metallization with nickel or gold. Overall, these characteristics make versatile platform, paving way for major biotechnological advances that were not possible current nanomaterials.