Selective toxicity of 1-naphthol to human colorectal tumour tissue
نویسندگان
چکیده
منابع مشابه
1-Naphthol: a potential selective antitumour agent.
A major problem in cancer chemotherapy is the lack of selective toxicity of many commonly used anti-cancer agents towards tumour tissue compared to normal tissue.1 This is due primarily to the fact that many of these drugs, such as the alkylating agents, attack rapidly dividing tissues of the host as well as the tumour. Another area of concern is the refractory nature of many solid tumours to e...
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In the title compound, C(10)H(6)N(2)O(5), the two fused rings are almost co-planar, with an r.m.s. deviation of 0.0163 Å. The nitro groups are oriented at dihedral angles of 2.62 (11) and 44.69 (11)° with respect to the plane of the parent fused rings. Intra-molecular O-H⋯O and C-H⋯O hydrogen bonds complete S(6) ring motifs. In the crystal, mol-ecules are linked into chains along [101] by inter...
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The title compound, C(11)H(9)NO(2), was prepared by a condens-ation reaction of 2-hydr-oxy-1-naphthaldehyde with hydroxyl-ammonium chloride in refluxing ethanol. An intra-molecular O-H⋯N hydrogen bond is observed. In the crystal structure, inter-molecular O-H⋯O and C-H⋯O hydrogen-bond inter-actions result in a two-dimensional network.
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The biotransformation of xenobiotics is essential to the maintenance of the body's integrity. Mucosal biotransformation has been well documented in the small and large intestine of animals and humans but whether the gastric mucosa plays a role in detoxifying ingested compounds remains largely unknown. The conjugation of the model phenolic compounds, 1-naphthol, by human gastric epithelial cells...
متن کامل5-Amino-1-naphthol
In the title compound, C(10)H(9)NO, the amino and the hydr-oxy groups act both as a single donor and a single acceptor in hydrogen bonding. In the crystal, mol-ecules are connected via chains of inter-molecular ⋯N-H⋯O-H⋯ inter-actions, forming a two-dimensional polymeric structure resembling the hydrogen-bonded mol-ecular assembly found in the crystal structure of naphthalene-1,5-diol. Within t...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1985
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1985.131