Selective serotonin reuptake inhibitors and risk for gastrointestinal bleeding

Selective serotonin reuptake inhibitors and risk of cerebral bleeding.

S elective serotonin reuptake inhibitors (SSRIs) are used commonly to treat poststroke depression. They are also being evaluated in clinical trials for their effectiveness in facilitating functional recovery after stroke. 3,4 However, observational studies suggest that SSRIs are associated with several adverse outcomes in older people (aged >65 years), including an increased risk of all-cause m...

Selective Serotonin Reuptake Inhibitors

It has long been postulated that a deficiency in CNS serotonergic activity is the cause of, or a predisposing factor for, depression. [1] However, the evidence for this association is largely circumstantial and it certainly does not represent an adequate and full model for depression, probably due to there being multiple aetiological factors. [2] Some pharmacological trial data also cast doubt ...

Selective serotonin reuptake inhibitors.

Selective Serotonin Reuptake Inhibitors and Gastrointestinal Bleeding: A Case-Control Study

BACKGROUND Selective serotonin reuptake inhibitors (SSRIs) have been associated with upper gastrointestinal (GI) bleeding. Given their worldwide use, even small risks account for a large number of cases. This study has been conducted with carefully collected information to further investigate the relationship between SSRIs and upper GI bleeding. METHODS We conducted a case-control study in ho...

Selective serotonin reuptake inhibitors and risk for major congenital anomalies.

OBJECTIVE To estimate the risk of major congenital anomalies after exposure to selective serotonin reuptake inhibitors during pregnancy. METHODS A retrospective cohort study based on national population-based registers (years 1996-2006) of births, congenital anomalies, and terminations of pregnancy because of severe fetal anomalies (maintained by National Institute for Health and Welfare, sou...