Selective Gelatinase Inhibitor Neuroprotective Agents Cross the Blood-Brain Barrier
نویسندگان
چکیده
منابع مشابه
Gelatinase B modulates selective opening of the blood-brain barrier during inflammation.
Matrix metalloproteinases (MMPs) are associated with neuroinflammatory diseases, and blood-brain barrier damage is a pathophysiological consequence of central nervous system inflammation. We examined whether an increase in MMP production is coupled with the breakdown of blood-brain barrier integrity in the lipopolysaccharide (LPS)-injured brain. Rat brain stimulated with LPS showed a significan...
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ژورنال
عنوان ژورنال: ACS Chemical Neuroscience
سال: 2012
ISSN: 1948-7193,1948-7193
DOI: 10.1021/cn300062w