Selective expression of RAG-2 in chicken B cells undergoing immunoglobulin gene conversion
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چکیده
منابع مشابه
Selective expression of RAG-2 in chicken B cells undergoing immunoglobulin gene conversion.
Chickens create their immunoglobulin (Ig) repertoires during B cell development in the bursa of Fabricius by intrachromosomal gene conversion. Recent evidence has suggested that Ig gene conversion may involve cis-acting DNA elements related to those involved in V(D)J recombination. Therefore, we have examined the potential role of the V(D)J recombination activating genes, RAG-1 and RAG-2, in re...
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Site-specific recombination of immunoglobulin and T cell receptor gene segments in B and T lymphocytes is dependent on the expression of two recombinant activation genes, Rag-1 and Rag-2. Here, we show that RAG-1 protein turnover in pre-B cells depends on the expression of RAG-2. The apparent half-life of RAG-1 protein is increased when RAG-2 is not expressed in differentiating pre-B cells.
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ژورنال
عنوان ژورنال: Cell
سال: 1991
ISSN: 0092-8674
DOI: 10.1016/0092-8674(91)90221-j